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Fostering new paradigms for the biological sciences

THOMAS A. KNOTTS IV

Chemical and Biological Engineering Graduate Program

Department of Chemical and Biological Engineering

Faculty Advisor: Juan de Pablo

taknotts@wisc.edu
262-2448

Resume 2005 (PDF FIle)

THOMAS A. KNOTTS IV

The purpose of my research is to develop and employ advanced simulation and modeling techniques to describe the behavior of biological molecules. I apply sophisticated Monte Carlo and molecular dynamics methods to predict the thermodynamic properties of systems of interest.

Currently, I am engaged in understanding the fundamental process of DNA hybridization. Hybridization is essential to life, and is exploited in many modern experimental techniques in genomic science, yet very little is known about the process. In future work, I will examine the manner in which regulatory proteins recognize and bind to DNA at specific sites. Simulation provides the tools to analyze, at an atomistic level, the intricacies of these phenomena.

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