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Yeast
cells are constantly changing their gene expression
mechanisms in order to efectively respond to fluctuations
in stresses; varying from low nutrient availability,
rapid temperature change as well as exposure to drugs,
and each stress induces a specific response critical
for the cell's survival. My research will investigate
specific mechanisms that the budding yeast, S. cerevisiae,
uses to coordinate the precise change in genomic expression
responding to stress. We predict that chromatin-remodeling
proteins regulate stress-dependent gene expression in
yeast. I will investigate whether mutatnts in chromatin-remodeling
proteins are sensitive to different environmental stresses.
In addition, I will characterize gene experssion in
chromatin remodeling mutants on a genome-wide scale.
I will identify genes whose expression i dependent on
specific chromatin remodeling proteins to test our hypothesis
that stress related genes are regulated by changes in
chromatin state.
Search
PubMed for Publications
Paolo
P. Provenzano, Adriana L. Alejandro-Osorio, Wilmot B.
Valhmu, Kristina T. Jensen and Ray Vanderby, Jr., "Intrinsic
fibroblast-mediated remodeling of damaged collagenous
matrices in vivo", Matrix Biology, In
Press.
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