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Cytokinesis
is an important and fundamental process in the
development of all organisms. The factors that
establish the cleavage furrow have remained
mysterious and have eluded many for over 130
years. The goal of my research project is to
identify factors involved in cleavage furrow
formation by combining proteomics, bioinformatics,
RNAi assays and high-resolution in vivo microscopy
techniques. This multi-pronged approach should
give a global view of the factors that function
during specific phases of the cell cycle and
an insight into the role that particular proteins
play during this time.
Currently, my research focuses on identifying
proteins involved in metaphase and metaphase-anaphase
staged spindles by mass spectrometry analysis.
I intend to use reverse genetic techniques to
explore the roles of homologs of these proteins
in Caenorhabditis elegans.
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