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My
postdoctoral research is focused on development
of novel protein/peptide identification and
quantification technology based on gas-phase
reactions and mass spectrometry. We propose
a radical based fragmentation method to achieve
several advantages compared to existing technologies:
higher sensitivity to detect low abundance peptides/proteins;
greater protein sequence coverage; simpler spectra
leading to higher confidence in peptide ID assignment,
and simpler instrumentation. Quantification
will be achieved using new labeling chemistries
with stable isotopes.
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