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My
research focus is studying the mechanisms by
which global gene expression is regulated by
kin28, an essential kinase, involved in phosphorylation
of the C-terminal domain (CTD) of RNA polymerase
II. In order to study kin28-mediated regulation
of transcription and to begin to understand
the relevance of the CTD code, kin28 will be
irreversibly inhibited in vivo, and global gene
expression profiles analyzed. The long-term
goal is to construct a complete genome-wide
CTD modification profile using computational,
bioinformatics, and biochemical approaches.
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